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Contact: Jeff Misakian, Valeant Pharmaceuticals 714-545-0100 ext. 3309 VALEANT PHARMACEUTICALS RECEIVES FDA MARKETING APPROVAL FOR CANNABINOID CESAMETTM CII ; COSTA MESA, Calif., May 16, 2006 Valeant Pharmaceuticals International NYSE: VRX ; today announced that the U.S. Food and Drug Administration FDA ; has given marketing approval for Cesamet CII ; nabilone ; oral capsules. Cesamet is used to treat nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments. "There is still a significant unmet need in treating one of the most feared and severe consequences of life-saving cancer therapies, " said Timothy C. Tyson, Valeant's president and chief executive officer. "With the approval of Cesamet, Valeant is proud to offer a solution that will help alleviate one of the most common side effects of chemotherapy." Cesamet is a synthetic cannabinoid that is thought to act as an omnineuromodulator interacting with the cannabinoid receptor, CB1, which is present throughout the nervous system. This receptor is involved in regulating nausea and vomiting. Because of this omnineuromodulation, the mechanism of action for Cesamet is significantly different from conventional anti-emetics. Cesamet has a long duration of action, which allows for less frequent dosing, typically twice daily. Valeant acquired Cesamet from Eli Lilly & Company in 2004 and currently sells Cesamet in Canada, where the product has an 86 percent share of the cannabinoid market, according to IMS Compuscript data from February 2006. Last year, Valeant entered into an agreement with Par Pharmaceutical Companies, Inc. NYSE: PRX ; to promote Cesamet in the United States. Valeant anticipates launch of Cesamet in the next several weeks following approval. "In my practice, Cesamet has been used successfully to treat patients with chemotherapyinduced nausea and vomiting, " said Paul Daeninck, M.D., assistant professor, Department of Oncology at the University of Manitoba in Winnipeg, Canada. "We have found that it offers longacting chemotherapy-induced nausea and vomiting relief in a well-tolerated and convenient twice-aday regimen and alesse. If you happen to overdose on accupril, seek medical attention immediately.

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1. Damage to the cerebellar hemisphere is characterized by A. head bobbing B. inability to maintain a standing posture with the eyes closed Romberg's sign ; C. tendency to veer in the direction of the affected hemisphere D. circumduction gait E. hemiparesis of the ipsilateral limb 2. Common causes of acute ataxia include all of the following EXCEPT: A. drug intoxication B. ataxia telangiectasia C. acute post-infectious cerebellitis D. neuroblastoma E. hydrocephalus 3. All of the following statements are true about acute post-infectious cerebellitis EXCEPT: A. it is characterized by rapid onset of ataxia B. it occurs following viral infections such as mumps, coxsackie B and varicella infections C. CSF is characterized by marked pleocytosis D. it has excellent prognosis E. it usually begins approximately 2 weeks after a viral illness. General Definition NOTE: Red, bold italic type indicates new or edited definitions, GPRA measures in yellow ; Refusal of ASA other anti-platelet: REF refusal of any ASA or anti-platelet medication in sitepopulated medication taxonomies DM AUDIT ASPIRIN DRUGS or BGP ANTI-PLATELET DRUGS at least once during the period admission visit date through the 180 days after discharge visit date. Contraindications to ASA other anti-platelet defined as any of the following occurring ever unless otherwise noted: A ; Patients with prescription for Warfarin Coumadin using sitepopulated BGP CMS WARFARIN MEDS taxonomy during the period admission visit date through the 180 days after discharge visit date; B ; Hemorrhage diagnosis POV 459.0 C ; NMI not medically indicated ; refusal for any aspirin at least once during the period admission visit date through the 180 days after discharge visit date; or D ; CPT G8008 Clinician documented that AMI patient was not an eligible candidate to receive aspirin at arrival ; at least once during the period admission visit date through the 180 days after discharge visit date. Adverse drug reaction documented ASA other anti-platelet allergy defined as any of the following occurring anytime up to the 180 days after discharge visit date: A ; POV 995.0-995.3 AND E935.3; B ; "aspirin" entry in ART Patient Allergies File or C ; "ASA" or "aspirin" contained within Problem List or in Provider Narrative field for any POV 995.0-995.3 or V14.8. ACEI ARB Numerator Logic: Ace Inhibitor ACEI ; medication codes defined with medication taxonomy BGP HEDIS ACEI MEDS. ACEI medications: Benazepril Lotensin ; , Captopril Capoten ; , Enalapril Vasotec ; , Fosinopril Monopril ; , Lisinopril Prinivil Zestril ; , Moexipril Univasc ; , Perindopril Aceon ; , Quinapril Accuprul ; , Ramipril Altace ; , Trandolopril Mavik ; . ACEI-Combination Products: Benazepril + HCTZ Lotensin HCT ; , Captopril + HCTZ Capozide, Hydrochlorothiazide + Capropril ; , Enalapril + HCTZ Vaseretic ; , Fosinopril + HCTZ Monopril HCT ; , Lisinopril + HCTZ Prinzide, Zestoreti, Hydrochlorothiazide + Lisinopril ; , Moexipril + HCTZ Uniretic ; , Quinapril + HCTZ Accuretic ; . Refusal of ACEI: REF refusal of any ACE Inhibitor medication in site-populated medication taxonomy BGP HEDIS ACEI MEDS at least once during the period admission visit date through the 180 days after discharge visit date. Contraindications to ACEI defined as any of the following: 1 ; Diagnosis ever for moderate or severe aortic stenosis POV 395.0, 395.2, 396.0, or 747.22 ; or 2 ; NMI not medically indicated ; refusal for any ACEI at least once during the period admission visit date through the 180 days after discharge visit date. Adverse drug reaction documented ACEI allergy defined as any of the following occurring anytime up to the 180 days after discharge visit date: 1 ; POV 995.0-995.3 AND E942.6; 2 ; "ace inhibitor" or "ACEI" entry in ART Patient Allergies File or 3 ; "ace i * " or "ACEI" contained within Problem List or in Provider Narrative field for any POV 995.0-995.3 or V14.8. ARB Angiotensin Receptor Blocker ; medication codes defined with medication taxonomy BGP HEDIS ARB MEDS. ARB medications: Candesartan Atacand ; , Eprosartan Teveten ; , Irbesartan Avapro ; , Losartan Cozaar ; , Olmesartan Benicar ; , Telmisartan Micardis ; , Valsartan Diovan ; . ARB Combination Products: Candesartan Atacand HCT ; , Irbesartan Avalide ; , Losartan Hyzaar ; , Telmisartan Micardis HCT ; , Valsartan Diovan HCT ; . Refusal of ARB: REF refusal of any ARB medication in site-populated medication taxonomy BGP HEDIS ARB MEDS at least once during the period admission visit date through the 180 days after discharge visit date. Contraindications to ARB defined as any of the following: 1 ; Diagnosis ever for moderate or severe aortic stenosis POV 395.0, 395.2, 396.0, ; or 2 ; NMI not medically indicated ; refusal for any ARB at least once during the period admission visit date through the 180 days after discharge visit date. Adverse drug reaction documented ARB allergy defined as any of the following occurring anytime up to the 180 days after discharge visit date: 1 ; POV 995.0-995.3 AND E942.6; 2 ; "Angiotensin Receptor Blocker" or "ARB" entry in ART Patient Allergies File or 3 ; "Angiotensin Receptor Blocker" or "ARB" contained within Problem List or in Provider Narrative field for any POV 995.0-995.3 or V14.8!

Debt is actually another great way to generate cash, but historically only large, well financed biotech companies have been able to raise hundreds of millions of dollars from the sale of convertible debentures. Smaller firms, if they used converts at all, could only sell those instruments that had a variable rather than fixed ; conversion price. Because the investors benefited when the company's stock price went down and down again ; , this particular type of financing earned a reputation as a toxic or death spiral convert. And, of course, privately held firms if they wished to raise cash through a debt financing had to turn to traditional lenders like Comerica Bank to get their money. These days, venture-backed private firms as well as selected small-cap public companies ; can turn to Hercules Technology Growth Capital Inc., which provides them with $10 million to $20 million in cash through debt financings. Debt has a number of advantages including the facts that it is non-dilutive and cheaper than an equity transaction. On the other hand, the debt has to be paid back, and if the biotech company experiences a materially adverse change, the lender can call the loan. Over the last 18 months, Hercules has provided $101 million total in venture debt to eight private biotech companies. It also participated with other investors in a $44 million Series E round for QuatRx Pharmaceuticals Co. in May 2007. Indeed, venture debt and equity financings can and do exist side-byside. In some cases, the debt can help a fledgling firm to achieve its next milestone event, the sort that will attract more equity investors. According to Kathy Conte, Hercules' managing director of life sciences, venture debt is not a new type of financing. "I have been lending money to venture-backed life sciences companies for 15 years." However, the types of companies involved have changed, she explained. At one time, Hercules focused on deals with healthcare providers and physician practices, for instance, but the ascendance of the biotech sector attracted venture capital, and "the debt followed that, " she said. The typical arrangement, Conte said, involves a three-year term loan but is structured to match the biotech firm's clinical development timeline. "The source of repayment is the next round of equity, she explained, although Hercules "does not demand repayment from that equity." The loan from Hercules "will amortize. Each month the [biotech] company pays a little bit of the principal. By the end of 36 months, they will have paid it all, " she said. Importantly, if the same company then "raises money through equity, it does not change the amortization schedule of the loan." "Equity is appropriate for clinical trials and other high-risk activities, " she said. "If a company is out of money and [its product] is in a mid-stage clinical trial, it's a bad time to incur debt. If the only source of [debt] repayment" is that one experimental compound, the situation becomes risky. That's why Hercules likes to deal with companies that have more than one compound in development: "If a compound fails, the company can still survive." Indeed. There seems to be no end to the ways in which biotechs and specialty pharmas can raise money. According to Paul Capital's Flamenbaum, "The healthcare industry is capital-intensive. As long as companies need money, there will be a response." And there's at least one niche for each investor, for example, acckpril drug.
The department of health has power, now contained in the health act 1999, to limit prices of pharmaceuticals and control the profits of pharmaceutical companies. Three large prospective randomised survival trials have now consistently shown a reduction in mortality by 34 35 % [13] Figs. 1, 2, table 1 ; . Two trials, CIBIS II and COPERNICUS, usFigure 1: KaplanMeier curves of cumulative percentage of total mortality p value adjusted for two interim analyses ; . From [1] with permission.

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