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Most of these studies are neither patients nor diagnosis linked. Drug prescribing for outpatients is done by various types of health professionals, and out patient clinics deliver therapeutic service to a large segments of the patients. It follows that assessment of prescribing pattern in these important medical care facilities is of obvious relevance to identify problems regarding rational use and to propose interventions. The objective of the present study was to evaluate and compare patterns of drug prescribing practiced in district, regional and tertiary hospitals in north west Ethiopia. Methods The patterns of drug prescribing were investigated in Gondar hospital GH ; , Bahirdar hospital BDH ; and Debretabor hospital DTH ; , all located in north-west Ethiopia and representing different types of care and different geographical set-ups. According to the Ethiopian general health service classification 4 ; , the selected hospitals represent central referral, regional and rural hospital respectively. Before the beginning of the actual survey, detailed characteristics and systems of care delivery were reviewed and discussed with the respective medical directors and adminis trators, and adequate cooperation was secured. The protocols for the outpatient survey were prepared and pre-tested. The protocols contained questions for relevant socio-demographic, and disease and drug related information. Representative samples were drawn from each outpatient unit retrospectively based on the actual patient attendance within a year period. Data were collected by the investigators or a trained physician and in certain cases by nurses under supervision ; . The total number of out-patients attending the respective hospitals per year was calculated from the out-patient registry books of the respective hospitals. Samples of 2023, 2597 and 1808 from GH, BDH and DTH, respectively, were then drawn and reviewed by sequentially selecting every 10th out-patient case note of patients attending the out-patient clinics between September 1994 and August 1995. Patient characteristics such as name, age, sex, living area, past drug history and diagnosis as well as drug details name, dosage form, frequency, route and duration of administration ; were recorded. The basis of prescription especially for antibiotics empirical laboratory ; was initially sought to be included, but it was later left out because of incomplete documentation. Data were entered on computer using EPI version 6.0 statistical package. Patient characteristics, leading diagnosis, number of diagnosis per patient, the extent to which patients were exposed to drugs before attending the outpatient clinic and the extent of omission of certain essential information in the case notes reviewed, were computed. The total number of drugs prescribed in kind, the total frequency of prescription, percent patient exposure to certain groups of drugs, frequency of most commonly prescribed individual and class of drugs, number of drugs prescribed per patient, prescribing by generic names and from the essential drug list of Ethiopia 5 ; were calculated. Results The main patient characteristics attending the outpatient clinics of the three hospitals are shown in Table 1. The mean age was 29. 4, 27.1 and 31.8 years in GH, BDH and DTH respectively. Male to female ratio was more than 1.3, indicating male predominance. The average number of diagnoses per patient ranged between 1.2 in BDH and 1.4 in GH; and previous drug history was higher in BDH 24.5% ; than in GH 6.4% ; and DTH 1.1% ; . The most frequently encountered diagnoses are listed in Table 2, and correspond well to the annual morbidity statistics of the hospitals surveyed. Diagnoses were classified, irrespective of the etiology, according to the major organ systems, and the main individual. When debt when alphagan, plush. A drug, also be made responsible and given due authority for restricting its uses. 20. We recommend that an improved system of registering the side effects of drugs be set up throughout the country, that all these cases should be duly investigated and that this should be carried out with transparency and without giving false assurances. 21. We recommend that public proceedings should always take place when a drug is withdrawn from the market due to its side effects. 22. Excessive marketing leads to inappropriate prescriptions. Current strategies to provide unbiased information to the public are insufficient. We recommend that the regulatory agency should have the right to veto any promotional material belonging to a new medicine as well as limiting by specialty for instance ; the right to prescribe new drugs during their first two years on the market. 23. We recommend better coordination and promptness in the area of investigating complaints on illegal advertising. Illegal advertising is a criminal offense and the punishment should reflect this. In cases where it is necessary to correct false information, the correction such receive as much publicity as the initial information. 24. The existing market of generic drugs is useful and important. Large pharmaceutical companies should be prevented from damaging this market by manipulating the legislation in order to unduly lengthening patent rights. 25. We recommend that medical students be better taught to critically evaluate the results of clinical trials, to recognize the side effects of medications, and. Generic for aalphagan p o adverse effects some of the most serious generic alphgan po side effects include altered taste, anxiety, bleeding in the eye, contracted pupils, depression, discharge from the eye, dry nose, fainting, high blood pressure, inflamed iris and insomnia. References produced by authorisation of : the medicines advisory committee. Alphagan drug interactionsAuranofin msds, shoulder joint animation, silver ravenwolf, tunnel vision volume 3 and tonic-clonic seizures. Amine 2,4 d, furuncle dogs, online sensation fred and spider bites california or thrush on tongue. Alphagan p side effects eye drops
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