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Issues in developing drugs specifically for children and adolescents. TBD Animal models of juvenile depression. Kevin H. Happe, Creighton University School of Medicine Posttranscriptional Regulation of Gene Expression Chair: J. David Port Posttranscriptional regulation of gene expression: A regulatory paradigm for G-protein coupled receptors. J. David Port, University of Colorado Health Sciences Center Role of TTP in modulation of TNF alpha expression. Perry J. Blackshear, NIEHS, NIH, Research Triangle Park, NC MAPK-dependent phosphorylation of mRNA binding proteins and regulation of myogenic transcripts. Roberto Gherzi, National Institute for Cancer Research, Genoa, Italy Post-transcriptional regulation of cyclin expression in breast cancer. Rebecca S. Hartley, University of New Mexico Health Science Center P Cardiovascular Pharmacogenomics: From Theory to Practice? Chair: Dan M. Roden Genetics and genomics of antiarrhythmic therapy. Dan M. Roden, Vanderbilt University School of Medicine Genetic and genomic markers of response to antihypertensive therapy. Julie A. Johnson, University of Florida Predicting drug response in hypercholesterolemia. Ronald M. Krauss, Children's Hospital Oakland Research Institute Pre-prescription genotyping in heart failure: a concept whose time is near? Michael R. Bristow, University of Colorado Health Science Center Ray Fuller Symposium: Promise and Pitfalls in the Search for New Drugs Targeted at Metabotropic Glutamate Receptors Chair: Darryle D. Schoepp mGluR5 negative allosteric modulators: in line for multiple clinical proof of concept testing. Vincent Mutel, Addex Pharmaceuticals, Plan Les Ouates, Switzerland Roles of mGluRs in synaptic plasticity: implications for therapeutic interventions. Graham L. Collingridge, University of Bristol, U.K. Allosteric potentiators of metabotropic glutamate receptors as a novel approach for treatment of CNS disorders. P. Jeffrey Conn, Vanderbilt University mGlu receptors: Beyond the regulation synaptic transmission. Ferdinando Nicoletti, University of Catania, Italy MONDAY, April 30, 3: 00 5: 30 Early Clinical Development Strategies for Monoclonal Antibody Experimental Agents in Non-Oncology Indications Chair: Mary A. Mascelli Anti IL-12 23 monoclonal antibody for psoriasis: Biomarker validation of mechanism-of-action and disease pathogenesis. Kevin D. Cooper, Case Western Reserve University and University Hospitals of Cleveland Early development of drugs with new mechanisms of action. Question-based rather than study-based development. Adam F. Cohen, Center for Human Drug Research, Leiden, The Netherlands Immune response analysis for monoclonal antibodies in development: Past experience and new expectations. Carrie L. Wagner, Centocor, Inc. Regulatory considerations related to the design of early clinical trials of monoclonal antibody experimental agents. 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