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See: c ; Sawayama, T.; Tsukamoto, M.; Sasagawa, T.; Nishimura, K.; Deguchi, T.; Takeyama, K.; Hosoki, K. Chem. Pharm. Bull. 1990, 38, 110. d ; Blackburn, C.; Pingali, A.; Kehoe, T.; Herman, L. W.; Wang, H., Kates, S. A. Bioorg. Med. Chem. Lett. 1997, 7, 823. Natoff, I. L.; Redshaw, S. Drugs of the Future 1987, 12, 475. a ; Wyvratt, M. J.; Tristram, E. W.; Ikeler, T. J.; Lohr, N. S.; Joshua, H.; Springer, J. P.; Arison, B. H.; Patchett, A. A. J. Org. Chem. 1984, 49, 2816. b ; Blacklock, T. J.; Shuman, R. F.; Butcher, J. W.; Sohar, P.; Lamanec, T. R.; Shearin, W. E.; Grabowski, E. J. J. Chem. Ind. Dekker ; 1992, 47, 45. c ; Blacklock, T. J.; Shuman, R. F.; Butcher, J. W.; Shearin, W. E. Jr., Budavari, J.; Grenda, V. J. J. Org. Chem. 1988, 53, 836. d ; Iwasaki, G.; Kimura, R.; Numao, N.; Kondo, K. Chem. Lett. 1988, 1691. e ; Huffmann, M. A.; Reider, P. J. Tetrahedron Lett. 1999, 40, 831. a ; Urbach, H.; Henning, R. Tetrahedron Lett. 1984, 25, 1143. b ; Arcadi, A.; Bernocchi, E.; Cacchi, S.; Marinelli, F.; Scarinci, A. Synlett 1991, 177. a ; Flynn, G.; Beight, D. W. Tetrahedron Lett. 1988, 29, 423. For related works, also see: b ; Iwasaki, G.; Kimura, R.; Numao, N.; Kond, K. Chem. Pharm. Bull. 1989, 37, 280. c ; Fujisawa, T.; Ito, T.; Fujimoto, K.; Shimizu, M., Wynberg, H.; Staring, E. G. J. Tetrahedron Lett. 1997, 9, 1593. c ; Kubota, H.; Nunami, K.; Hayashi, K.; Hashimoto, Y.; Ogiku, N.; Matsuoka, Y.; Ishida, R. Chem. Pharm. Bull. 1992, 40, 1619. Baker, W. R.; Condon, S. L. Tetrahedron Lett. 1992, 33, 1577. Kricheldorf, H. R. -Amino Acid N-Carboxy Anhydrides and Related Heterocycles; Springer: Berlin, 1987. a ; Palomo, C.; Aizpurua, J. M.; Ganboa, I.; Oiarbide, M. Amino Acids 1999, 16, 321. b ; Palomo, C.; Aizpurua, J. M.; Ganboa, I.; Oiarbide, M. Pure Appl. Chem. 2000, 72, 1763. c ; Palomo, C.; Aizpurua, J. M.; Ganboa, I.; Oiarbide, M. Synlett 2001, 18113. For more information on this subject, see: a ; Palomo, C.; Aizpurua, J. M.; Ganboa, I.; Oiarbide, M. Eur. J. Org. Chem. 1999, 3223. b ; Georg, G. I.; Ravikumar, V. T. In The Organic Chemistry of -Lactams Georg, G. I.; Ed.; VCH: New York, 1993; pp 295-368. a ; Hubschwerlen, C.; Schmid, G. Helv. Chim. Acta 1983, 66, 2206. b ; Hubschwerlen, C.; Specklin, J.-L. Org. Synth. 1998, 9, 13. Wagle, D. R.; Garai, G.; Chiang, J.; Monteleone, M. G.; Kurys, B. E.; Strohmeyer, T. W.; Hedge, V. R.; Manhas, M. S.; Bose, A. K. J. Org. Chem. 1988, 53, 4227. For the application of this concept in ketene-imine cycloaddition, see: a ; ref. 9a. b ; Palomo, C.; Ganboa, I.; Cuevas, C.; Boschetti, C.; Linden, A. Tetrahedron Lett. 1997, 38, 4643. c ; Niu, C.; Petterson, T.; Miller, M. J. J. Org. Chem. 1996, 61, 1014. Hong, Y. L.; Shing, T. K. H. J. Org. Chem. 1997, 62, 2622. a ; Palomo, C.; Oiarbide, M.; Esnal, A. Chem. Commun. 1997, 691. b ; Palomo, C.; Oiarbide, M.; Esnal, A.; Landa, A.; Miranda, J. I.; Linden, A. J. Org. Chem. 1998, 63, 5838. c ; Sim, T. B.; Rapoport, H. J. Org. Chem. 1999, 64, 2532, because cardura mg.
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