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Ho, Benjamin Ong Objectives and Methods: To compare the NUH thrombolysis outcome with that of the NINDS t-PA Stroke Trial NTST ; and to ascertain if early CT brain changes and increased age affected outcome. Patients with acute ischaemic stroke meeting the NTST guidelines modified to an arbitrary age 65 years and treated with intravenous tissue plasminogen activator t-PA ; from January 1998 to April 2000 were reviewed. Results and Discussion: The outcome at 3 months compared to that of NTST in parenthesis is as follows: Nine patients with a mean age of 60.9 years NTST 67 years ; were thrombolysed. 33.3% were females NTST 42% ; . 66.6% NTST 8% ; had early CT changes. We could not directly compare our patients' neurological deficits with the NTST because a different score was being employed. 22.2% NTST 50% ; patients had a favourable outcome. They were younger and had fewer medical conditions and better neurological scores then those with moderate to severe outcome or death. The proportion with early CT changes was comparable in all groups. An NTST subgroup analysis reported that early CT findings, diabetes, hypertension and deficit severity but not the patient's age predicted poor outcome without affecting the benefits of t-PA therapy. Despite being younger, our patients had a 44.4% death i.e 2.6 times that of the NTST. Of the 4 patients who died, 2 were caused by haemorrhagic transformation and 2 from large infarcts with mass effect. These patients shared comparable variables with, and were in fact a little younger and with normal CTs when compared to the moderate to severe outcome group. Therefore we were unable to see a trend in predicting potential deaths or haemorrhagic transformation. An NTST subgroup analysis found that deficit severity and early CT changes predicted symptomatic hemorrhages but not the outcome at 3 months. Though our study is very small, the higher mortality rate is of concern and we will closely monitor the trend. Meanwhile, we will continue to adhere to the NTST guidelines as the evidence so far shows that even older patients and those with early CT findings respond favourably to t-PA therapy despite an increase in symptomatic hemorrhages. Objective: Choosing proper outcome measures is important for producing reliable results in clinical trials and systematic reviews. We analyzed outcome measures used in Chinese acute stroke trials to see if appropriate clinically relevant outcomes were used. Methods: Randomised controlled trials RCTs ; on acute stroke published before 1997 from the Chinese Stroke Trials Register were included. For each trial, we recorded types of outcome measures used, year of publication, sample size, blinding of outcome assessment, statistical methods used for analysis and the significance of the results. Types of outcomes used were classified as four levels: 1. Pathology. 2. Impairment. 3. Disability. 4. Handicap quality of life. Results: Sixty RCTs were included in this analysis. 40% 24 60 ; of the trials used outcomes in pathology level, 80% 48 60 ; in impairment level, 8% 5 60 ; in disability level and none in quality of life level. Only 23% 14 60 ; of the trials reported number of death but none of them used death as an outcome measure. Results in 95% 57 60 ; of the trials were favorable to the tested interventions. Conclusions: In Chinese acute stroke trials, outcome measures used were mainly in pathology and impairment levels and very few trials used functional outcome or death. The proportion of positive results in these trials was high. More clinically relevant outcomes should be used in future Chinese stroke trials, because generic famvir. Do not take famvir if you are allergic to penciclovir denavir ; without first talking to your doctor. 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