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Tip. Since the venogram was not obtamed for diagnostic purposes, no attempt was made to fill the venous nadides completely. Arteniography was performed to localize a pheochromocytoma and identify the blood supply to the tumor. Patients were routinely pretreated with an alpha blocker, phenoxybenzamine hydrochloride Dibenzyline ; , and. O you have an asthma story to share with others? Perhaps it's a lesson that you learned about living with asthma, an anecdote that would help others deal with their asthma, or a special way that you have learned to manage your asthma. We'd like to hear from you and to have the opportunity to share your experiences with other readers of Breath of Fresh Air. Please send us your asthma story by mail Partners Asthma Center, 15 Francis Street, Boston, MA 02115 ; , by e-mail asthma partners ; , or by fax 617-732-7421, att'n: Christopher Fanta, M.D. ; . Thank you in advance for sharing your story. All of us at Partners Asthma Center wish you a Happy and Healthy New Year, for example, phenoxybenzamine.
Are you interested in serving on Passport Health Plan's Pharmacy and Therapeutics Committee? If so, please call, write, or e-mail: Thomas Kaye, RPh., MBA 305 W. Broadway, Suite 300 Louisville, KY 40202 502-585-7986 E-mail: Thomas.Kay amerihealthmercy.

Table 11 continuation ; Dose no. of injections ; , mg kg Phdnoxybenzamine Phenoxybenzaminf Phenoxybezamine Phen0xybenzamine Phenoxyb nTamine Phentolamine Piperoxane -adrenergic receptor blocking agents DL-Propanolol DL-Propanol ol DL-MetoproIol DL-MetoproIol DL-MetoproIol DA receptor blocking agents Pimozide Pimozide Pimozide Pimozide Fluspirilene 5 2 ; 10 Time of injection h ; 14, 16 14, Number of eggs Md Semiquartile deviation 9 10 9 Sample size Percentage non--ovulating rats 0 30 0 16.6 0 0 40 Degree of blockade t.

Health canada rejects rbgh by monsanto called posilac, a genetically-engineered hormone, which is injected into cows to increase milk production. L-Arginine is an essential amino acid and a nitric oxide precursor. Nitric oxide has been shown to be the neuro-transmitter in the efferent autonomic cavernosal nerves which is released following sexual stimulation. Nitric oxide has also shown to be the factor which is released following sheer stress forces from new arterial inflow along the lacunar space endothelial surfaces. Whether released from neural or endothelial sources, nitric oxide ultimately plays a major role in the induction of penile smooth muscle relaxation following sexual stimulation. Nitric oxide is synthesized from L-Arginine and molecular oxygen in the presence of the enzyme nitric oxide synthase and a PO2 level exceeding 55 mm Hg. Very few documented studies of LArginine use as a treatment for erectile dysfunction have been published. In one study, L-Arginine had been given to 20 impotent patients in a stable relationship. Placebo was given for 2 weeks and LArginine for 2 weeks. 2. Alpha-Blocking Agents--Phentolamine Alpha-1 and Alpha-2 ; Phenotolamine hydrochloride is a competitive alpha-adrenergic antogonist with similar affinity for Alpha-1 and Alpha-2 adrenoceptors. In addition, phentolamine can block receptors for serotonin. Phentolamine also has a direct, non-specific relexant effect on blood vessels. There have been several publications converning the use or oral phentolamine and the treatment of erectile dysfunction. Although most have been small studies in single institutions. In 1994, in an open label trial, Zornioti reported in impotent men the use of 50 mg of Phentolamine against 10 mg of Phenoyxbenzamine along acting Alpha Blocking Agent ; 1.5 hour prior to intercourse. Forty two percent were able to erect for intercourse with phentolamine against 9% with phenoxybenzamine. In a single blind trial also in 1994, Zorgnitti compared 20mg buccal phentolamine with placebo give 20-30 minutes prior to intercourse. Thirty two percent were able to erect for intercourse with phentolamine while only 13% were able to erect for intercourse with placebo. Gwinup [19] in 1988 reported that 69% of men with unspecified impotence were able to penetrate 11 12 hours later following 50mg. oral phentolamine; only 3 16 19% ; of similar men responded to placebo. Brooks in 1992 reported that 2 impotent diabetic improved erections taking oral phentolamine. Trazodone Hydrochloride Alpha-1 ; Trazodone hydrochloride is a typical anti-depressant without antimuscarinic effects. It is selective and phenytoin.

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When you have a physical illness like heart disease, it can be easy to focus only on becoming physically healthier. Don't overlook how your conditions affect you emotionally and mentally. Having heart disease can be stressful and even frightening as you learn to cope with the changes in your lifestyle and the realization that you have a serious illness. Ignoring signs of excess stress or depression can put extra strain on your heart, making it harder to recover. This section can help you understand and deal with the mental changes you may experience as a result of your condition. Precautions caution in tachycardia, peptic ulcer, and gastritis; cerebrovascular occlusions and myocardial infarctions can occur following administration drug name phenoxybenzamine dibenzyline ; - noncompetitive alpha-adrenergic blocker and valsartan.
Date & Time Fri 01 19 2001 p.m. CT Source s ; General Hospital General Hospital, Electrocardiogram Page 504 machine generated no provider listed Fact Text Description EKG report reveal: Premature Ventricular Contraction Normal Sinus rhythm with occasional premature ventricular contraction a k a PVC The contraction of the cardiac * Otherwise Normal EKG ventricle prior to the normal time, caused by an electrical impulse to the ventricle arising from a site other than the sinoatrial node. The PVC may be a single event or occur several times in a minute or in pairs or strings. Three or more PVCs in a row constitute ventricular tachycardia. Fri 01 19 2001 p.m. CT General Hospital General Hospital, Admission History and Physical S--S--, M.D. Page 69 Admission H & P reveals: Reports to the Emergency with extreme pain and was unable to provide a very accurate past medical history other than; Chief Complaint: Injury to leg from accident with mechanical equipment. Physical Examination: do not address GI specifically, but notes: * Abdomen Unremarkable. Diagnosis: 1 ; Open comminuted displaced intra-articular fracture of the distal right tibia and fibula. 2 ; Loss of circulation of the right foot. Fri 01 19 2001 00 p.m. CT General Hospital G.H. Physician Progress Notes page 201-202 S--S--, M.D. General Hospital General Hospital, Anesthesia Evaluation Page 96 R--R--, M.D. Physician Progress Note reveals; Patient and his mother were explained x-rays and severe nature of injury and that patient may lose his leg. Extensive surgery is necessary on the fractured bones and damaged blood vessels and there were many risks with the surgery and his leg would never be normal. Pre post Anesthesia Evaluation reveals; Central nervous system, cardiovascular, respiratory, endocrine, kidney and liver are all noted as negative No family history of anesthesia problems Patient had back surgery with general anesthesia, with no problems Recent drug therapy and or current medications states as "none.
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The diagnosis of reflux esophagitis is made in case of endoscopically documented alterations of the esophageal mucosa. Some these patients may be asymptomatic. Barretts esophagus develops because of reflux, whether this is symptomatic or not, whether it caused changes of eshophagitic type or not. Gastro-esophageal reflux is favoured by a number of factors: nutrition, drugs, smoking, obesity, pregnancy, hiatal hernia, surgery. They interfere with one or more links of the antireflux physiological mechanisms 3, 8 ; . Thus the diaphragm hiatus, Hiss angle and the pressure of the lower esophageal sphincter LES ; are the main antireflux anatomical factors. In most patients a low tone is found normal value ~ 20-25 mmHg ; or relaxation periods without swallowing. Effective function is reduced in hiatal hernia with the LES situated intrathoracically. The LES tonus is influenced by food: proteins and sugars increase tonus, lipids lower it; by drugs: anticholinergic drugs, teophylline, calcium channel blockers decrease tonus, and so do alcohol in large amounts and smoking. Esophageal motility is altered in patients with GERD. In almost one third of them the peristaltic waves have a smaller amplitude and are less frequent. This has a negative effect on the clearance mechanisms of the esophagus. Another important cleansing factor is saliva. The lower saliva secretion in smokers explains the important role of smoking in GERD. Clinostatism also favours stagnation of the refluxed material in the esophagus, thus gravitation is no longer a mechanism of esophageal cleaning. Gastric motility disturbances and delayed stomach emptying increase inner gastric pressure, which induces hypersecretion and favours aggressive reflux. Large meals and excessive consumption of bubbly fluids have the same effect. Duodenal stenoses ulcerous, malignant, congenital ; are constantly associated with severe esophagitis. The aggressive nature of the refluxed material is an important pathogenetic factor. Ulcer patients with acid hypersecretion develop esophagitis more often. Also, the duodeno-gastric reflux may bring to the esophagus duodenal juice rich in bile acids and pancreatic enzymes which aggravate esophageal injury. It seems the Barretts esophagus evolution depends especially on the presence of bile acids in the refluxed content 10 ; . In fact the aggressiveness depends on the composition. Hydrochloric acid most probably causes columnar metaplasia, as a gastric type mucosa is developed in the esophagus. Esophagitis lesions are probably induced by pepsin which is activated in acid environment. However, intestinal metaplasia may also be determined by other component substances such as pancreatic trypsin or bile acids. Studies performed on the refluxed content have found conjugated bile acids, taurocholic and glycocholic, as well as dehydroxylated, taurodeoxicholic and deoxicholic, in the patients with Barretts esophagus. The action of tauroconjugated or unconjugated bile acids could be enhanced by the presence of hydrochloric acid and nevirapine.

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For a full discussion of maximum minimum inventory control systems, see Family Planning Logistics Management FPLM ; . 2000. The Logistics Handbook: A Practical Guide for Supply Chain Managers in Family Planning and Health Programs. Arlington, Va.: FPLM John Snow, Inc., for the U.S. Agency for International Development. Figure 6 Time-course of changes in plasma [Asn1, Val5]-Ang II ; in rainbow trout administered a ; 09% NaCl control; n 7 ; , b ; the smooth muscle relaxant, papaverine 10 mg kg; n 7 ; , c ; papaverine 10 mg kg ; after pretreatment with the -adrenoceptor antagonist, phenoxybenzamine n 7 ; , d ; the ACE inhibitor, lisinopril 10 4 mol kg; n 7 ; , or e ; lisinopril 10 4 mol kg ; followed by papaverine 10 mg kg; n 7 ; . Saline, papaverine and lisinopril injections were carried out before the 10-min sampling time. For a given treatment: * significant difference from the 0-min value in graphs a ; , b ; , and c ; , and from the 10 min value in graphs d ; , and e significant difference from the corresponding value in the papaverine-treated b ; animals; significant difference from the corresponding value in the control a ; animals P 005 ; . Values are means + S.E.M and didanosine.

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The mean Poot was 82 mm H tempts to elevate g the Pcoe above this level in these animals resulted in severe hypotension. The mean blood l s in the COI os phenoxybemamine hydrochloride treated animals os was 1.75 38 ml. Although the estimated blood l s in these animals was considerably lower than in other hypercarbic animals, the mean value for thres hour blood loss was still highly signifiant when compared to air breathing animals. The last column o Table 2 l s the animals subf it jected to "lesser" elevations of COI. This group has been compared to the phenoxybenzamine hydrochloride-treated animals which & had a lower mean PaCG than other hypercarbic animals. The mean blood loss of the Tesser'' COI p u p was 3.0 ml. While the numbers of animals compared were small, the diffemce in t e mean values of the W r h blood loss was not significant Thus, significant blood losses were observed in all hypercarbic animals when compared to the air breathing animals. h Figure 1 shows the gross section of t e small intestine of carbon dioxide-breathing animals. The specimens obtained from the air-breathing animals showed no abnormalities. In t e COr breathing h.

Categories all categories science & mathematics agriculture alternative astronomy & space biology botany chemistry earth sciences & geology engineering geography mathematics medicine physics weather zoology other - science resolved question show me another closed to new answers k kiki member since: 31 januari 2007 total points: 648 level 2 ; points earned this week: -% best answer kiki my login and videx. Loride is a medication used for the tr, for example, side affects.

The eHealth Strategy of the WHO: Problems and Prospects Molecular Medicine and Individualized Healthcare: Defining the Research Agenda How Can Computer Simulations of Biological Processes Support Medical Decision Making? and digoxin. Other manifestations of the syndrome . Patients with medullary carcinoma and their family members should also be evaluated for other manifestation of the MEN syndromes--hyperparathyroidism and pheochromocytoma. This can be accomplished by regular screening of the blood pressure, serum calcium, and parathyroid hormone determinations and urinary studies for epinephrine, norepinephrine, metanephrine, normetanephrine, and vanyl mandelic acid VMA ; . Medullary carcinoma, whether sporadic or familial, can also secrete adrenocorticotropic hormone ACTH ; ectopically, which results in adrenal cortical hyperplasia and Cushing syndrome. In such cases a bilateral adrenalectomy is occasionally necessary. Removal of all the thyroid cancer in such a case would also be curative but this is rarely possible since usually widely metastatic disease is present when the ectopic ACTH syndrome occurs. Finally, some persons develop diarrhea. This condition is usually associated with bulky deposits of metastatic disease and may be the result of serotonin, prostaglandin, or calcitonin secretion. If a patient with medullary carcinoma is also recognized to have a pheochromocytoma, the adrenal tumor, or tumors, should be operated on first because of the dangers inherent in this tumor during daily life and especially under anesthesia. Preoperative treatment with a-adrenergic blockade using phenoxybenzamine Dibenzyline ; or another alpha blocker is routine. Beta-Adrenergic receptor blockade is used selectively for tachycardia or arrhythmias. It is an absolute maxim that proper patient monitoring, careful anesthetic management, skillful pharmacologic manipulations to prevent hypertension and hypotension, and a gentle, "nontraumatic" operative approach are necessary to achieve excellent results. Frequently a bilateral total adrenalectomy is necessary to remove all tumor or to ablate the adrenal medullary hyperplasia completely. A total thyroidectomy is always indicated for medullary carcinoma of the thyroid. 24 In addition, a very extensive central node dissection should be performed. Single or bilateral lateral node dissections should be performed if the lymph nodes in these areas are involved with tumor. 25Few would disagree with this aggressive operative regimen, because medullary carcinoma, a C-cell tumor, does not concentrate RAl and is not responsive to T4 therapy. Radiotherapy is used for nonresectable residual tumor; however, the tumor is sometimes not very radiosensitive. Occasional metastatic tumors have responded favorably to adriamycin and other agents, but chemotherapeutic regimens have not been generally effective. Treatment with multiple agents. Muscle or joint pain ache your doctor or nurse can recommend medication and other strategies to relieve pain and dipyridamole. One thing that definitely worked for us was complete and total honesty. We told Robert that we understood patching would be uncomfortable at first and he wouldn't want to do it. We explained that it was necessary to strengthen a weak eye muscle and the better he was at keeping the patch on the quicker his eye would strengthen and the patching would be finished. We told him that people especially adults ; were very silly when they said hurtful things like "Oh poor boy! What happened to his eye", and that adults need to be told what the patch is.

Completely impaired on a psychiatric basis "[d]ue to his lack of ability to develop insight and to tolerate and deal with the situation." Earl N. Metz, M.D., the chairman of the medical review board for the retirement board, recommended approval of Hulls's application for disabilityretirement benefits on the condition that Hulls secure psychiatric treatment. Hulls and persantine!

FLAMM, Y AS ARGIL, RANSOHOFF 11. Lieberman AN, Gardner AL, Goodgold AL, et al: Chronic vasospasm following subarachnoid hemorrhage: Treatment with phenoxybenzamine. Presented at the Combined Meeting of the New England and New York Neurosurgical Societies. Mt. Sinai Hospital, New York, November 13, 1970 15. Kapp J, Mahaley MS, Odom GL: Cerebral arterial spasm, Parts 1-3. J Neurosurg 29: 3 Taylor SH, Sutherland GR, MacKenzie GJ, et al: The circulatory effects of phentolamine in man with particular respect to changes in forearm blood flow. Clin Science 2 8 : 265-284, 1965 17. Yashon D, Dunker RO Jr, Locke GE, et a l : vitro basilar and common carotid artery reactivity to alpha and beta stimulation. Neurology 2 1 : 1085-1087, 1971 18. Nickerson M : Drugs inhibiting adrenergic nerves and structures innervated by them. In Goodman LS, Gilman A eds ; : The Pharmacological Basis of Therapeutics. New York, MacMillan, edition 4, p 549-584, 1970.

5 , spiney member join date: oct 2006 81 i have been on this particular medication for several months with mixed results and disopyramide and phenoxybenzamine, for example, phehoxybenzamine mechanism. If you are a public school retiree and you did not enroll in a prescription drug plan by May 15, 2006, you will have to wait until November 15, 2006 to become eligible to join. At that time, your premium cost will increase by at least 1% per month for every month that you waited to join. This penalty will have to be paid as long as you have Medicare prescription drug coverage. For additional information, please call 1-800-MEDICARE 1-800-633-4227 ; . If you are a State retiree of a state-sponsored health insurance plan, your Rx benefit will remain the same: $10 for generic, $25 for formulary name brand drugs, and $50 for non-formulary name brand drugs. It is not necessary for you to enroll in a Medicare Part D pharmacy plan. Investigators but rather at recent trends in the populations of new investigators and trainees. The actual number of first time M.D. applicants for NIH research project grants has plummeted in the past few years from 838 in 1994, to 687 in 1995, to 589 in 1996, to 575 in 1997 -- a 31 percent fall Figure 4 ; . Since first-time applicants had about a 22 percent success rate in 1997, this means that in 1997 only 126 M.D.s in the entire country were successful the first time they sought to be P.I.s on an NIH research project grant. If this progression were to continue linearly, there would be no first-time M.D. applicants by 2003. Furthermore, the drop in first-time M.D. applicants was not made up by M.D. Ph.D.s; there have been fewer than 200 first-time applicants from this group annually and their number shows no significant trend. These data indicate that progressively fewer young M.D.s are interested in or perhaps prepared for ; careers as independent NIH-supported investigators. This unhappy conclusion is supported by examining data on trainees. In 1980 the total number of M.D. postdoctoral trainees supported by NIH through individual fellowships and training grants was 2, 241; this number rose during the 80's and then plateaued; but since 1992, the actual number has fallen steadily. In 1992 the number was 2, 613; in 1997, 1, 261 -- a 51 percent decrease. When the number of M.D.s and Ph.D.s is expressed as a fraction of all trainees, the course of events during the past decade is starkly graphic Figure 5 ; . If this trend is not changed, there will be no M.D.s in this pool by 2006. Recent data from the Howard Hughes Medical Institute are just as discouraging. In the past two years, the number of M.D.s and M.D. Ph.D.s applying for the prestigious HHMI postdoctoral fellowships has fallen from 276 in 1996 to 152 in 1998 a 45 percent drop. Finally, we should note the results of the annual questionnaire of the Association of American Medical Colleges completed by all graduating medical students in the country Figure 6 ; . In 1989, 14 percent expressed a strong interest in research as a career; that fraction fell in almost each successive year, reaching 10 percent in 1996. The human pipeline of physician-scientists is emptying at the worst possible spot -- the young end. Now I want to turn to the second question I posed: Does it matter if physician-scientists constitute a smaller and smaller segment of the community of medical researchers, and perhaps ultimately even disappear? After all, some say, there are plenty of well-trained Ph.D.s and many of them are now doing clinical research. If and norpace.

TABLE 2. NEW DOSAGE FORMS AND INDICATIONS APPROVED BY THE FDA: JANUARY 1 MARCH 19, 2005 Generic Name Brand Name Company ; Indication Dosage Form Date.

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Try to take this medicine at the same time each day.
This study just provides the evidence to demonstrate what hundreds of thousands of doctors already know - that this source of information has become an indispensable part of medical practice, that helps us improve care, said allen bennett, facp, internist, hematologist oncologist and chairman of the committee on medical ethics at the medical society of the state of new york.

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For further information contact: beverly friedman, office of regulatory policy hfd-007 ; , food and drug administration, 5600 fishers lane, rockville, md 20857, 301-594-204 supplementary information: the drug price competition and patent term restoration act of 1984 public law 98-417 ; and the generic animal drug and patent term restoration act public law 100-670 ; generally provide that a patent may be extended for a period of up to years so long as the patented item human drug product, animal drug product, medical device, food additive, or color additive ; was subject to regulatory review by fda before the item was marketed, because hpenoxybenzamine cat.

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Phenoxybenzamine, an alpha-adrenoceptor blocker, is also reported to be helpful in alleviating pain, 18 including cold-induced pain, in some cases and phenytoin.

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Photodermatitis, Triggered by or actinic exposure to dermatitis sunlight after taking certain oral drugs e.g., certain antibiotics, diuretics, antihistamines, and antidepressants ; or topical chemicals e.g., organic sunscreens ; . Reaction may be delayed with some oral medications. Eczema appears on light-exposed areas, such as the face, back of hands, forearms, and tips of the ears. In rare cases, can become chronic. Stasis Dermatitis Poor circulation. May produce swelling edema ; , inflammation, ulcers, and itching skin usually in the lower leg. My profile login register directory search faq forum home » flare sci-fi forums » community » the flameboard » drug interaction meets the big white bus author topic: drug interaction meets the big white bus jubilee plete with cherries.
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Email this article print this article what is the most important information i should know about phenoxybenzamine. World Health Organization Information sheets on Integrated Management of Childhood Illness IMCI ; . : whqlibdoc.who.int hq 1998 WHO CHS CAH 98.1 A-M ; REV.1 1999 Management of Childhood Illness in developing countries: Rationale for an integrated strategy. WHO CHS CAH 98.1A REV.1 1999 Integrated Management of Childhood Illness: Global status of implementation WHO CHS CAH 98.1B REV.1 1999 Planning national implementation of IMCI WHO CHS CAH 98.1C REV.1 1999 Adaptation of the IMCI technical guidelines and training materials WHO CHS CAH 98.1D REV.1 1999 IMCI training course for first-level health workers: Linking integrated care and prevention WHO CHS CAH 98.1E REV.1 1999 Follow-up after training: Reinforcing the IMCI skills of first level health workers WHO CHS CAH 98.1F REV.1 1999 The role of IMCI in improving family and community practices to support child health and development WHO CHS CAH 98.1G REV.1 1999 Update on development projects to support IMCI WHO CHS CAH 98.1H REV.1 1999 IMCI research priorities: Investigating methods t prevent and manage childhood illness WHO CHS CAH 98.1I REV.1 1999 Introducing IMCI into pre-service training for health professionals WHO CHS CAH 98.1J REV.1 1999 IMCI indicators, monitoring and evaluation WHO CHS CAH 98.1K REV.1 1999 Integrated Management of Childhood Illness and health sector reform WHO CHS CAH 98.1L REV.1 1999 Building partnership for child health WHO CHS CAH 98.1M REV.1 1999, for example, agonist. Do not stop taking phenoxybenzamin3 without talking to your doctor.
Read more 9 vote who slams tobacco industry for spreading false info on smoking posted by brunetoo may 31 2007 site ; category : health tags : asthma cancer pneumonia the world health organization on tuesday slammed the tobacco industry for spreading false information on smoking in public places as it called for more international efforts to ensure smoke-free environments. 7N20RF. This table also includes false positive FP ; and false negative FN ; percentages for all tissue classes.

INFECTION CONTROL INFECTION CONTROL LOCATION: DEPT. PHONE: CLINICAL BEEPER STAFF: Regions Hospital 1st Floor, North Building, Suite 110 651 ; 254-3489 651 ; 629-0556 Dede Ouren, RN, CIC, Infection Control Manager Catriona Mann, RN, Infection Control Practitioner Stephanie Tismer, RN, Infection Control Practitioner Theresa Cain, RN, ICP QMC Thomas Michels, RN, HealthPartners Clinic ICP Dina Bougie, Infection Control Associate Joan Perkins, Administrative Assistant 651 ; 254-2001 651 ; 629-0663 651 ; 629-0037 651 ; 629-0942 651 ; 629-2529.
P .05; P .01; observed cases analysis. CIBIC-Plus Clinician's Interview-Based Impression of Change Plus Caregiver Input. Adapted with permission from Corey-Bloom J, et al. International Journal of Geriatric Psychopharmacology. 1998; 1: 55-65.
Inside the and medical phenoxybenzamine refore capable positive result person. Second day of treatment. On the third day, one drop of 0.5 per cent solution of propranolol was applied prior to the application of epinephrine. At this time, the mean intraocular pressure in the treated eyes was 2.4 0.3 6 ; mm. Hg less than in the control eyes, and the corresponding mean pupil diameter difference was 0.0 0.1 6 ; mm Hg. One hour after the application of the propranolol and the epinephrine the mean intraocular pressure in the treated eyes was 0.3 6 ; mm. Hg less than in the control eyes, and the corresponding pupil diameter difference was 5.5 0.2 6 ; mm Hg. At six hours, the mean pressure in the treated eyes was 4.6 0.3 6 ; mm. Hg less than in the control eyes, and there was almost complete recovery of the pupil diameter. In three untreated normal conscious rabbits, the application of one drop of 0.5 per cent propranolol gave no significant pressure decrease over a period of five hours. Discussion In our previous study of the ocular response to epinephrine, the experimental observations were limited to the first twenty-four hours.10 Under these conditions, a submaximal dose of epinephrine caused an immediate pupillary response which preceded a decrease of intraocular pressure. The pupillary response was prevented, and the pressure response was partially inhibited by an intravenous injection of the a-adrenergic receptor antagonist, phenoxybenzamine. Under the same experimental conditions, the pupillary response to epinephrine was unaffected and the pressure response partially inhibited by the -receptor antagonist, propranolol. It was concluded that the pupillary response was dependent solely on stimulation of a-adrenergic receptors, and that the pressure response was dependent on stimulation of both a- and -receptors. Furthermore, there was a difference in the time courses of the pressure responses mediated by the a- and -receptors in that the.

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